Evolution of raltegravir resistance during therapy
نویسندگان
چکیده
منابع مشابه
HIV resistance to raltegravir
Similar to all antiretroviral drugs, failure of raltegravir-based treatment regimens to fully supress HIV replication almost invariably results in emergence of HIV resistance to this new drug. HIV resistance to raltegravir is the consequence of mutations located close to the integrase active site, which can be divided into three main evolutionary pathways: the N155H, the Q148R/H/K and the Y143R...
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Methods 25 plasmas from HIV-1 infected patients with HAART failure were studied. Genetic analysis was performed amplifying and sequencing DNA encompassing 288 amino acids of HIV-1 integrase gene. Drug resistance mutations and polymorphisms were examined following Low et al, 2009. Genetic subtypes were analyzed using REGA HIV Subtyping Tool (http://www.bioafrica.net/ subtypetool/html/subtypinghi...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2009
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/dkp153